Search results for "Asthma control test"

showing 9 items of 9 documents

Overrating Classifier Performance in ROC Analysis in the Absence of a Test Set: Evidence from Simulation and Italian CARATkids Validation

2019

Background The use of receiver operating characteristic curves, or “ROC analysis,” has become quite common in biomedical research to support decisions. However, sensitivity, specificity, and misclassification rates are still often estimated using the training sample, overlooking the risk of overrating the test performance. Methods A simulation study was performed to highlight the inferential implications of splitting (or not) the dataset into training and test set. The normality assumption was made for the classifier given the disease status, and the Youden's criterion considered for the detection of the optimal cutoff. Then, an ROC analysis with sample split was applied to assess the disc…

Male020205 medical informaticsperformance estimatorsmedia_common.quotation_subjectHealth Informatics02 engineering and technology03 medical and health sciences0302 clinical medicineHealth Information ManagementSurveys and QuestionnairesStatisticstrue predictive performanceRinite Alérgica0202 electrical engineering electronic engineering information engineeringmedicineHumanssample splitComputer Simulation030212 general & internal medicineChildAsmaNormalityAsthmaMathematicsmedia_commonAdvanced and Specialized NursingReceiver operating characteristicasthma control testasthma control test sample split performance estimators optimal cutoff simulation study true predictive performanceDiscriminant validityReproducibility of ResultsEstimatormedicine.diseasesimulation studyRhinitis AllergicAsthmaConfidence intervalROC CurveTest setoptimal cutoffFemaleClassifier (UML)
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Alveolar nitric oxide and asthma control in mild untreated asthma

2012

Background The role of the peripheral airways in asthma is increasingly being recognized as a potential target for the achievement of optimal control of the disease. We postulated that the inflammatory changes of the small airways are implicated in the lack of asthma control in mild asthma. Objective To test this hypothesis, we measured the alveolar fraction of exhaled NO (C alv NO) in patients with mild asthma with different levels of control of symptoms. Methods Seventy-eight patients with asthma (35 men, age, 37 ± 15 years; FEV 1 percentage of predicted, 100% ± 9%) were studied. Asthma control was assessed by using the Asthma Control Test (ACT). Measurements of exhaled NO at multiple con…

AdultMalemedicine.medical_specialtyVital capacityImmunologySettore MED/10 - Malattie Dell'Apparato RespiratorioNitric OxideGastroenterologyNitric oxideYoung Adultchemistry.chemical_compoundFEV1/FVC ratioAsthma controlInternal medicinemedicineHumansImmunology and AllergyYoung adultAsthmabusiness.industryExhalationmedicine.diseaseAsthmaRespiratory Function Testsrespiratory tract diseaseschemistryExhalationAnesthesiaFemalebusinessAsthma Control TestJournal of Allergy and Clinical Immunology
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Effects of a structured educational intervention in moderate-to-severe elderly asthmatic subjects.

2019

Background: Adherence to inhaled drugs is linked to patients’ satisfaction with their device, and an incorrect use can negatively affect the outcomes of asthma treatment. We speculated that this is particularly true in elderly asthmatic subjects. Aim: We performed a national pre-post interventional multicentre study, enrolling moderate-to-severe asthmatic subjects aged ≥65 ​years treated with fixed inhaled combination drugs by dry powder inhaler (DPI) or pressurized metered dose inhaler (pMDI). Adherence and critical errors were evaluated by means of validated questionnaires at first visit (V1) and after 3–6 months (V2). At V1, subjects underwent intensive training on the correct use of the…

Vital capacityACT asthma control testExacerbationSAE severe asthma exacerbationSF12chlorofluorocarbonsmental health composite scoreEDUCA elderly and device use in chronic asthmaPCS physical health composite scoreACT asthma control test; AHDS hospital anxiety depression scale; Asthma; CFC chlorofluorocarbons; Device misuse; EDUCA elderly and device use in chronic asthma; Education; Elderly; FEV1 forced expiratory volume 1s second; FVC forced vital capacity; ICS inhaled corticosteroids; LABA long-acting β2 agonist; LAMA long-acting muscarinic antagonists; MCS mental health composite score; PCS physical health composite score; PROs patient-reported outcomes; SAE severe asthma exacerbation; SF12 short form health survey; mMRC modified medical research councilEDUCAFEV10302 clinical medicineElderlyImmunology and AllergyMedicine030223 otorhinolaryngologybiologymMRC modified medical research councilsevere asthma exacerbationmodified medical research councilLAMASAELamaelderly and device use in chronic asthmaMetered-dose inhalerDry-powder inhalerDevice misusePROs patient-reported outcomesCFCPCSpatient-reported outcomesmMRClcsh:Immunologic diseases. AllergyPulmonary and Respiratory Medicinelong-acting β2 agonistmedicine.medical_specialtyImmunologyLABAphysical health composite scoreArticleLAMA long-acting muscarinic antagonistsAHDSEducation03 medical and health sciencesFEV1/FVC ratiolong-acting muscarinic antagonistsforced vital capacitySF12 short form health surveyAsthma; Device misuse; Education; ElderlyInternal medicineMCS mental health composite scoreforced expiratory volume 1s secondAsthmabusiness.industryFEV1 forced expiratory volume 1s secondInhalerasthma control testbiology.organism_classificationmedicine.diseaseCFC chlorofluorocarbonsACTICS inhaled corticosteroidsFVCAsthmaMCShospital anxiety depression scale030228 respiratory systemICSAHDS hospital anxiety depression scaleFVC forced vital capacityPROsshort form health surveyinhaled corticosteroidslcsh:RC581-607businessLABA long-acting β2 agonistThe World Allergy Organization journal
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Development of a nomogram to estimate the quality of life in asthmatic children using the Childhood Asthma Control Test

2016

Background: Pediatric Asthma Quality of Life Questionnaire (PAQLQ) provides detailed information on QoL in asthmatic children, whereas Childhood Asthma Control Test (C-ACT) Questionnaire is the most validated instrument for asthma control. No study assessed the relationship between C-ACT and QoL in children by means of those instruments. The aim of this study was to determine whether a QoL estimation is possible using the C-ACT questionnaire in asthmatic children. Methods: Medical history, spirometry, C-ACT, and PAQLQ were assessed in 144 (60% male) outpatient asthmatic children from September 2011 to November 2014. A generalized linear model (GLM) for the prediction of PAQLQ was obtained t…

SpirometryMalePediatricsmedicine.medical_specialtyPediatric Asthma Quality of Life QuestionnaireImmunologyPediatricsSeverity of Illness IndexChildhood Asthma Control Testnomogram03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineQuality of lifechildren030225 pediatricsSurveys and QuestionnairesSeverity of illnessMedicineImmunology and AllergyHumansMedical historyPreschoolChildAsthmaChildhood asthmaasthma; Childhood Asthma Control Test; children; control; nomogram; Pediatric Asthma Quality of Life Questionnaire; Asthma; Child; Child Preschool; Female; Humans; Italy; Male; Pediatrics; Prognosis; Reproducibility of Results; Severity of Illness Index; Spirometry; Surveys and Questionnaires; Nomograms; Quality of Life; Pediatrics Perinatology and Child Health; Immunology and Allergy; Immunologymedicine.diagnostic_testbusiness.industryReproducibility of ResultsNomogramPerinatology and Child Healthasthmamedicine.diseasePrognosisNomograms030228 respiratory systemItalySpirometryChild PreschoolPediatrics Perinatology and Child HealthQuality of LifeFemaleasthma; Childhood Asthma Control Test; children; control; nomogram; Pediatric Asthma Quality of Life Questionnaire; Pediatrics Perinatology and Child Health; Immunology and Allergy; Immunologybusinesscontrol
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Adherence to omalizumab: A multicenter “real-world” study

2020

Background: Adherence to medications is crucial in patients with severe asthma in light of the negative clinical impact and costs of non-adherence. Adherence to omalizumab has not been well studied in real-world settings. The aim of this study was to assess adherence to omalizumab and evaluate treatment effectiveness in relation to adherence. Methods: This was a retrospective, observational, and multicenter real-world study. Omalizumab dose, timing of administration, and duration of treatment ( 4 years) were analyzed. Adherence was evaluated by examining rates of expected and missing doses. Good adherence (10% doses missed) were determined. For effectiveness in relation to adherence of omal…

lcsh:Immunologic diseases. AllergyPulmonary and Respiratory Medicinemedicine.medical_specialtySevere asthmaEfficacySevere asthmaImmunologyOmalizumabOmalizumabSettore MED/10 - Malattie Dell'Apparato RespiratorioArticlePoor adherence03 medical and health sciences0302 clinical medicineInternal medicineImmunology and AllergyMedicineIn patient030223 otorhinolaryngologyAsthmaAsthma exacerbationsbusiness.industrySevere asthma Omalizumab Adherence Efficacy Real-worldmedicine.disease030228 respiratory systemReal-worldAdherenceObservational studylcsh:RC581-607businessAsthma Control Testmedicine.drug
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Asthma control in elderly asthmatics. An Italian observational study

2014

SummaryBackgroundThe exponential increase of individuals aged >64 yrs is expected to impact the burden of asthma. We aimed to explore the level of asthma control in elderly subjects, and factors influencing it.MethodsA multicenter observational study was performed on consecutive patients >64 years old with a documented physician-diagnosis of asthma. Sixteen Italian centers were involved in this 6-month project.FindingsA total of 350 patients were enrolled in the study. More than one-third of elderly asthmatic patients, despite receiving GINA step 3–4 antiasthmatic therapy, had an Asthma Control Test score ≤19, with a quarter experiencing at least one severe asthma exacerbation in the previo…

MalePulmonary and Respiratory MedicineChronic ObstructiveChronic bronchitismedicine.medical_specialtyExacerbationVital CapacitySettore MED/10 - Malattie Dell'Apparato Respiratorioelderly patientsPulmonary DiseasePulmonary Disease Chronic ObstructiveFEV1/FVC ratioElderlyForced Expiratory VolumeInternal medicinemedicineHumansAnti-Asthmatic AgentsAsthma control testAsmaAgedAsthmaCOPDAsma; elderly patientsAsthma; Asthma control test; Elderly; Aged; Anti-Asthmatic Agents; Asthma; Female; Forced Expiratory Volume; Humans; Male; Pulmonary Disease Chronic Obstructive; Treatment Outcome; Vital Capacitybusiness.industryOverlap syndromemedicine.diseaseAsthma control test; Elderly; AsthmaAsthmarespiratory tract diseasesTreatment OutcomeSalbutamolPhysical therapyFemaleObservational studybusinessmedicine.drug
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Serum lipoproteins are not associated with the severity of asthma

2018

Abstract Background Asthma is a chronic inflammatory disorder of the bronchi with a complicated and largely unknown pathogenesis . In this context, an emerging role is attributed to the apolipoproteins which serve as structural components of plasma lipoproteins . Low density lipoproteins (LDL) may be involved in the inflammatory pathways of the asthmatic airways; in particular, small dense LDL (sdLDL) particles were associated with increased oxidative susceptibility compared to medium and large sized LDL. In our previous study, we found a positive correlation between forced expiratory volume 1 s (FEV 1) % predicted and larger LDL particles (LDL-1), and an inverse correlation between FEV1% p…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyVital CapacityContext (language use)Low density lipoprotein030204 cardiovascular system & hematologyGastroenterologyPathogenesisYoung Adult03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineForced Expiratory VolumeInternal medicineHumansMedicinePharmacology (medical)Lung functionAgedAsthmaLungbusiness.industryBiochemistry (medical)Middle Agedmedicine.diseaseAsthmaLung functionLipoproteins LDLmedicine.anatomical_structure030228 respiratory systemCase-Control StudiesPotential biomarkersFemaleLDL subclassebusinessAsthma Control Test
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Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

2021

Abstract Background and aims Severe asthma is burdened by frequent exacerbations and use of oral corticosteroids (OCS) which worsen patients’ health and increase healthcare spending. Aim of this study was to assess the clinical and economic effect of adding mepolizumab (MEP) for the treatment of these patients. Methods Patients >18 years old, referred to 8 asthma clinics, starting MEP between May 2017 and December 2018, were enrolled and followed-up for 12 months. Information in the 12 months before mepolizumab were collected retrospectively. The evaluation parameters included: OCS use, number of exacerbations/hospitalizations, concomitant therapies, comorbidity, and annual number of workin…

OR Odds RatioPediatricsSevere asthmaExacerbationAnti IL-5; Comorbidities; Mepolizumab; OCS; Pharmacoeconomics; Severe asthmagastroesophageal reflux diseaseSettore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIOICS inhaled corticosteroidRate ratioOCS Oral Corticosteroidslaw.inventionComorbiditiesLAMA long acting muscarinic antagonist0302 clinical medicineRandomized controlled trialfractional nitric oxideInterquartile rangelawlong acting beta 2 agonistOdds RatioImmunology and AllergyRR Rate Ratio030223 otorhinolaryngologyPharmacoeconomicLOS Length of stayLOSIQRLAMAMEP MepolizumabORCISD Standard DeviationMEPPharmacoeconomicsACT Asthma Control TestComorbiditieCI Confidence Intervalsmedicine.druglcsh:Immunologic diseases. AllergyPulmonary and Respiratory Medicinemedicine.medical_specialtyinterquartile rangelong acting muscarinic antagonistImmunologyLABALABA long acting beta 2 agonistComorbidities Mepolizumab OCS Pharmacoeconomics Severe asthma Anti IL-5RRArticleRate Ratiochronic obstructive pulmonary disease03 medical and health sciencesPharmacoeconomicsOCS Oral CorticosteroidAsthma Control TestConfidence IntervalsFeNO fractional nitric oxideRCTs Randomized Controlled TrialmedicineCOPDGERD gastroesophageal reflux diseaseFeNOIQR interquartile rangeMepolizumabSDAsthmaRCTsOral Corticosteroidsbusiness.industryGERDmedicine.diseaseICS inhaled corticosteroidsACTComorbidityRandomized Controlled TrialsCI Confidence IntervalRCTs Randomized Controlled TrialsOCSCOPD chronic obstructive pulmonary disease030228 respiratory systemICSStandard DeviationLength of stayAnti IL-5inhaled corticosteroidslcsh:RC581-607businessMepolizumab
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Korelācijas starp astmas kontroles testu un astmas kontroles aptauju

2018

Virsraksts: Korelācija starp astmas kontroles testu un astmas kontroles aptauju Ievads: Svarīgi atzīmēt, ka astmas kontroles aptauja (ACQ) un astmas kontroles tests (ACT) ir pārtulkotas dažādās valodās, ko izmanto klīniskajos praksē un pētījumos pasaulē. Aptauju priekšrocība ir tāda, ka tās ir ārkārtīgi noderīgas astmas kontroles novērtēšanai un tiek lietotas daudzās pasaules valstīs. Attiecībā uz rezultātu interpretāciju un pārvaldību ACT un ACQ ir vispiemērotākās anketas. Mērķis: Šī darba mērķis bija noskaidrot korelāciju starp astmas kontroles testu un astmas kontroles aptauju un Globālās Astmas Iniciatīvas (GINA) astmas kontroles vērtējumu. Materiāli un metodes: Pētījuma populācijā ieti…

Asthma control questionnaireAsthma controlAsthma control testAsthmaMedicīna
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